Abstract
Infectious diseases along with various cancer types are among the most significant public health problems and the leading cause of death worldwide. The situation has become even more complex with the rapid development of multidrug-resistant microorganisms. New drugs are urgently needed to curb the increasing spread of diseases in humans and livestock. Promising candidates are natural antimicrobial peptides produced by bacteria, and therapeutic enzymes, extracted from medicinal plants. This review highlights the structure and properties of plant origin bromelain and antimicrobial peptide nisin, along with their mechanism of action, the immobilization strategies, and recent applications in the field of biomedicine. Future perspectives towards the commercialization of new biomedical products, including these important bioactive compounds, have been highlighted.
Highlights
Bromelain and Nisin: The NaturalOne of the tremendous burdens on human health worldwide is infectious diseases [1], where antibiotics act as first-line therapy in treating infections caused by bacteria
One pathogen organism is gaining resistance to more than one antibiotic, leading to the development of multidrug resistance strains for various species, such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), Salmonella spp., Enterococcus faecium (E. faecium), Campylobacter, Neisseria gonorrhoeae (N. gonorrhoeae), Streptococcus pneumonia (S. pneumonia) [2], etc
In vitro studies of bromelain and nisin show their potential in human medicine and healthcare, in the treatment of skin infections, caries, periodontal diseases, and many other conditions
Summary
One of the tremendous burdens on human health worldwide is infectious diseases [1], where antibiotics act as first-line therapy in treating infections caused by bacteria. Still, their widespread use, over-utilization and improper consumption in humans and animals cause an increase in the number of resistant bacterial strains. Pharmaceutics 2022, 14, 76 non-toxicity and low immunogenicity [9], researchers have begun to explore the nisin, an antimicrobial peptide with a broad-spectrum of antibacterial activity [6] as a potential alternative agent for infectious diseases [7]. Future perspective, the possibility to combine both bioactive components in an attempt to merge and even boost their multiple bioactivities, utilising diverse immobilization routes, have been brought forward
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
