Abstract

Brolucizumab and immunogenicity.

Highlights

  • Brolucizumab was approved on the basis of the pivotal phase 3 clinical trial results of the HAWK and HARRIER studies

  • It is important to understand this phenomenon in the light of the structure of these monoclonal antibodies used for retinal diseases and the historical data regarding inflammation caused by these molecules [Ranibizumab (Lucentis; Genentech, South San Francisco, CA) (Razumab; Intas Pharmaceutical Ltd, Ahmedabad, India) Bevacizumab (Avastin; Genentech, South San Francisco, CA), or Aflibercept (Eylea; Regeneron, Tarrytown, NY)]

  • Bevacizumab is a full-size humanized anti-VEGF monoclonal antibody, while ranibizumab is a humanized Fab fragment that neutralizes soluble splice variants and proteolytic fragments of VEGFA

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Summary

Introduction

Brolucizumab was approved on the basis of the pivotal phase 3 clinical trial results of the HAWK and HARRIER studies. The American Society of Retina Specialists (ASRS) released an alert reporting that apart from mild to moderate intraocular inflammation, there have been 14 cases of vasculitis. It is important to understand this phenomenon in the light of the structure of these monoclonal antibodies used for retinal diseases and the historical data regarding inflammation caused by these molecules [Ranibizumab (Lucentis; Genentech, South San Francisco, CA) (Razumab; Intas Pharmaceutical Ltd, Ahmedabad, India) Bevacizumab (Avastin; Genentech, South San Francisco, CA), or Aflibercept (Eylea; Regeneron, Tarrytown, NY)].

Results
Conclusion

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