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Abstract
An extensive study of two current ion mobility resolving power theories ("conditional" and "semi-empirical") was undertaken using a recently developed drift tube ion mobility-mass spectrometer. The current study investigates the quantitative agreement between experiment and theory at reduced pressure (4 Torr) for a wide range of initial ion gate widths (100 to 500 μs), and ion mobility values (K0 from 0.50 to 3.0 cm(2) V(-1) s(-1)) representing measurements obtained in helium, nitrogen, and carbon dioxide drift gas. Results suggest that the conditional resolving power theory deviates from experimental results for low mobility ions (e.g., high mass analytes) and for initial ion gate widths beyond 200 μs. A semi-empirical resolving power theory provided close-correlation of predicted resolving powers to experimental results across the full range of mobilities and gate widths investigated. Interpreting the results from the semi-empirical theory, the performance of the current instrumentation was found to be highly linear for a wide range of analytes, with optimal resolving powers being accessible for a narrow range of drift fields between 14 and 17 V cm(-1). While developed using singly-charged ion mobility data, preliminary results suggest that the semi-empirical theory has broader applicability to higher-charge state systems.
Highlights
In the early ion mobility literature, the term “resolving power” was used to characterize the precision and accuracy of an ion mobility spectrometer and was based on the sharpness of a single peak.[1,2] In its initial use, resolving power was a qualitative metric used to compare the relative capabilities of one ion mobility technique or instrument to another
We investigate the extent of agreement between ion mobility resolving power theories and experimental results obtained on a commercially-available ion mobility-mass spectrometer (IM-MS)
All of the β values measured in this work were well below 1, suggesting that the resulting ion pulse widths are narrower than would be expected from the time duration that the ions are admitted into the drift tube via the control software
Summary
In the early ion mobility literature, the term “resolving power” was used to characterize the precision and accuracy of an ion mobility spectrometer and was based on the sharpness of a single peak.[1,2] In its initial use, resolving power was a qualitative metric used to compare the relative capabilities of one ion mobility technique or instrument to another. Once the semi-empirical coefficients are determined for a wide range of gate widths and ion systems, eqn (7) can be expanded in order to generate a generalized resolving power expression which describes the performance of the current instrumentation.
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