Abstract

Medical librarians can expedite biomedical research by broadening the scope of their instruction curricula to include courses on the use of network visualization tools. With the dramatic increase in the number of databases, data sets, tools, and software being used to store, retrieve, and analyze proteomic, genomic, and metabolomic data, researchers are being forced to navigate an ever-complex information environment. Medical librarians can accelerate data analysis by learning about, conducting comparative analyses for, and providing instruction on these resources. Many libraries, such as the University of Florida's Health Science Center Libraries and Washington University's Bernard Becker Medical Library, offer instruction on biomedical databases and tools such as those provided by the National Center for Biotechnology Information (NCBI) [1, 2]. Instruction on network visualization tools is not as commonly provided by libraries. Network visualization is a method of data analysis that uses nodes to represent a data point, such as a gene, and edges (lines connecting nodes) to represent a relationship between two data points, such as an interaction between two genes (Figure 1, online only). Nodes and edges can have attributes associated with them that provide additional information, such as the chromosome on which a gene is located. Network visualization is an effective method for representing biologic relationships by succinctly highlighting properties and trends in complex systems. Networks also allow the integration of multiple different kinds of data such as gene expression, ontologies, and protein structures that have traditionally been stored in their own repositories [3]. Network analysis and network modeling techniques are being applied to biological networks in order to provide new hypotheses for biological systems, and as a result, a large number of tools for visualizing networks are constantly being developed, used, and reviewed [4]. Teaching biomedical resources such as network visualization tools, in addition to those developed by NCBI, is an area where medical librarians can make a significant impact. While resources like OpenHelix provide some instruction on these types of resources, these sources are limited, providing an important opportunity for libraries to expand the scope of their instruction curricula and to use instruction methods that allow broad participation by users. This paper discusses the evolution of a successful training class on a free and useful network visualization tool and the methods used to reach a wide-ranging audience.

Highlights

  • Cytoscape is a project dedicated to building open-source network visualization and analysis software

  • Applicable to any system of molecular components and interactions, Cytoscape is most powerful when used in conjunction with large databases of protein-protein, protein-DNA, and genetic interactions that are increasingly available for humans and model organisms

  • In order to ease the creation of formulas as well as to facilitate discovery of built-in functions we provide a formula builder in our attribute browser

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Summary

Introduction

Cytoscape is a project dedicated to building open-source network visualization and analysis software. This function is useful when importing a data table like the following (1): Unique ID A This data file is a tab-delimited text and contains network data (interactions), edge attributes, and node attributes. Users can specify columns containg source nodes, target nodes, interaction types, and edge attributes during file import. Cytoscape allows the user to add arbitrary node, edge and network information to Cytoscape as node/edge/network attributes This could include, for example, annotation data on a gene or confidence values in a protein-protein interaction. Node and edge attributes may be loaded at the command line using the –n and –e options or via the File → Import menu. As of Cytoscape 2.4, importing delimited text and MS Excel attribute data tables is supported Using this functionality, users can import data that isn't formatted into Cytoscape node or edge attribute file formats (as described above). If you need the most general functionality, please type the expression directly into a cell

A Note for Plugin Writers
General Procedure
Main Panel
Default Appearance Editor
Introduction to Visual Styles
Background
Continuous Mapper
To session file
Apply layout to the network
Select
Full Text
Published version (Free)

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