Abstract
Lorente de Nó came to Uppsala, Sweden, in 1924 to work with Robert Bárány, with the goal of studying the central nervous system pathways of the vestibular nystagmus response. Bárány’s 1907 book described a patient with a lesion involving the reticular formation of the pons close to the abducens nucleus who could generate only the slow phase of nystagmus. With stimulation, the patient’s eyes slowly deviated to one side and became pinned. The patient also had a loss of voluntary eye movements. Bárány concluded that there must be separate centers in the brainstem for the production of the slow and fast phases of nystagmus. He speculated that the center for generating fast phases was in the reticular substance next to the abducens nucleus and that this component was under the influence of cortical control. Nó would go on to perform studies of these central pathways for generating nystagmus in rabbit.
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