Abstract
AbstractPresented herein is the Brønsted acid (MsOH) mediated electrophilic sulfenylacyloxylation of o‐alkynylbenzoates via alkyne activation by in‐situ formed sulfonium cations from bench‐stable N‐thioaryl/alkyl‐succinimides followed by the intramolecular regioselective cyclization. The transformation provides access to structurally diverse 4‐sulfenylisocoumarins in 77–98% yields with broad functional group compatibility. The reaction scalability and reusability of phthalimide protecting group make this protocol synthetically viable.magnified image
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