Abstract
Abstract Trifluoromethanesulfonic acid (triflic acid) was found to be able to efficiently activate the benzylic sp3 C–F bond. Thus, under the catalysis of triflic acid at room temperature, trifluoromethylated arenes readily reacted with benzene to give benzophenones in moderate to good yields. Under similar B?nsted acid catalysis, intramolecular arylation also happened in the cases of some CF3‐arene substrates bearing an additional nucleophilic aryl group. Strong CF···H+ interaction or hydrogen bonding, is believed to play an important role in the current Br?nsted acid‐mediated C–F bond activation chemistry.
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