Abstract
Poly(glycerol sebacate) (PGS) is an aliphatic polyester which attracted significant scientific attention in recent years due to its vast potential in biomedical applications with regard to tissue engineering. It has been presented in the literature in the form of 2D films, porous scaffolds or nonwovens, to name just a few. Moreover, various applications have been proposed as a component of composite materials or polymer blends. Its physicochemical properties can be significantly adjusted by means of synthesis and post-synthetic modifications, including cross-linking or chemical modification, such as copolymerization. Many scientists have discussed PGS as a new-generation polymer for biomedical applications. Its regenerative potential has been confirmed, in particular, in tissue engineering of soft tissues (including nerve, cartilage and cardiac tissues). Therefore, we must anticipate a growing importance of PGS in contemporary biomedical applications. This brief review aims to familiarize the readers with this relatively new polymeric material for tissue engineering applications.
Highlights
There are multiple biocompatible polyesters developed for biomedical applications including poly(L-lactide), polycaprolactone or polyglycolide.[1]
A similar approach was used by Wang et al, who utilized digital-light-processing-based 3D printing for the production of nature-inspired double network (DN) from poly(glycerol sebacate) acrylate (PGSA).[29]
The in vitro degradation time, adhesion and proliferation abilities were investigated on bone marrow-derived mesenchymal stem cells (BMSCs) and articular chondrocytes (ACCs)
Summary
There are multiple biocompatible polyesters developed for biomedical applications including poly(L-lactide), polycaprolactone or polyglycolide.[1]. Poly(glycerol sebacate) is an excellent candidate for biomedical applications thanks to its physicochemical properties including its elastomeric capabilities,[2] cross-linking potential,[3] biodegrability[4] and biocompatibility[5] displayed in several in vitro and in vivo studies.
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