Brief report on the advantages of ovulation monitoring using home urinary LH immunoassays in ovulation induction cycles with a gonadotropin-releasing hormone agonist trigger

Abstract

Numerous medications are available to assist with follicular stimulation and ovulation induction in women with ovulatory dysfunction, including clomiphene citrate, aromatase inhibitors, and injectable gonadotropins. In patients that are at a higher risk for the development of ovarian hyperstimulation syndrome in an ovulation induction cycle, a gonadotropin-releasing hormone agonist trigger may be substituted for traditional hCG trigger at the expense of an increased potential for suboptimal response. When compared with serum luteinizing hormone (LH) evaluation, using a home urinary LH immunoassay for ovulation detection in gonadotropin-releasing hormone agonist agonist trigger cycles may serve multiple advantages. Accordingly, a home LH immunoassay may play a novel role as a safe, inexpensive and effective alternative to conventional phlebotomy, particularly in lower-resource settings.