Abstract
The publication deals with a brief overview of Hepatitis C Virus (HCV) and donor blood screening for HCV by using conventional Rapid, Enzyme Linked Immunosorbent Assay (ELISA) and Chemiluminescence Immunoassay (CLIA) also. The advantages of various generation of HCV tests in terms of sensitivity, specificity and reduction in window period are discussed.
Highlights
Human being has incredible creation of God having glandular important organ called liver
The Hepatitis C Virus (HCV) RNA is detectable by PCR as early as 1 week after exposure and HCV Ab develops in 2-6 weeks in acute infection but in some cases HCV Ab may not be positive for 6-9 months [7]
Screening assay is used for detection of HCV-Ab in the blood banks / diagnostic center but it does not discriminate between cleared infection and chronic infection [18,19,20]
Summary
Human being has incredible creation of God having glandular important organ called liver. The major root cause of viral hepatitis is either through contaminated water or infected blood or body fluids. The Hepatitis B virus (HBV) Hepatitis C Virus (HCV) and Hepatitis D Virus (HDV) infection are transmitted through infected blood, plasma derivatives, organ, tissues and contaminated needles etc. The HBV, HDV and HCV are the major causative agent of the liver disease, liver cirrhosis, liver failure and even liver cancer. The infection of more than one type of viral hepatitis HCV) is much more severe and fatal for human being than the person infected with single viral hepatitis disease. The use of highly sensitive HCV-Ab or HCV-Ag assay or HCV Ag-Ab assay or HCV-RNA by NAT reduce the seroconversion window period and increase the opportunity of clinician to start treatment early after exposure of the HCV and prevent the public from HCV infection
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