Brief communication on allele frequency of CYP3A4*22 in Indian population

Abstract

Cytochrome p450 3A4 polymorphism at CYP3A4*22 has become clinically significant due to its role in metabolizing various drugs. Therefore, in this study we established the frequency of CYP3A4*22 variant in Indian population. The allele frequency distribution was determined in 350 healthy subjects of Indian origin by Real time polymerase chain reaction method. We found that 97% of subjects has AA variant and 3% subjects has AG variant of CYP3A4*22. We did not find any homozygous minor allele AA variant. However, studies conducted in other population also did not show any homologous minor allele with exception to Belgium. The p-value of Hardy Weinberg equilibrium is observed as 0.9, which was calculated using the chi-square model. This study shows significant difference in the distribution of allelic variants of CYP3A4*22 among various ethnicities. Therefore, the study results may provide an insight in genotype distribution of the CYP3A4*22 in Indian population for further studies.