Abstract
In this study, Lu et al. investigated the ability of neural stem cells (NSCs) to repair the spinal cord following injury. Embryonic rat NSCs or human stem cell lines were embedded into fibrin matrices containing various growth factors and were grafted at spinal lesion sites in adult rats. After 7 weeks, around one-third of the grafted cells had differentiated into neurons, many of which extended axons that formed functional synapses with host neurons. Furthermore, axon outgrowth was found to be dependent on mammalian target of rapamycin signalling. Importantly, electrophysiological analysis suggested synaptic transmission and functional recovery of spinal cord relay circuits.
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