Abstract

The concept of prolonged field care (PFC), or medical care applied beyond doctrinal planning timelines, is the top priority capability gap across the US Army. PFC is the idea that combat medics must be prepared to provide medical care to serious casualties in the field without the support of robust medical infrastructure or resources in the event of delayed medical evacuation. With limited resources, significant distances to travel before definitive care, and an inability to evacuate in a timely fashion, medical care during exploration spaceflight constitutes the ultimate example PFC. One of the main capability gaps for PFC in both military and spaceflight settings is the need for technologies for individualized monitoring of a patient’s physiological status. A monitoring capability known as the compensatory reserve measurement (CRM) meets such a requirement. CRM is a small, portable, wearable technology that uses a machine learning and feature extraction-based algorithm to assess real-time changes in hundreds of specific features of arterial waveforms. Future development and advancement of CRM still faces engineering challenges to develop ruggedized wearable sensors that can measure waveforms for determining CRM from multiple sites on the body and account for less than optimal conditions (sweat, water, dirt, blood, movement, etc.). We show here the utility of a military wearable technology, CRM, which can be translated to space exploration.

Highlights

  • Significant distances to travel before definitive care, and an inability to evacuate in a timely fashion, medical care in space constitutes the ultimate prolonged field care (PFC)

  • Values of compensatory reserve measurement (CRM) over progressive Lower-body negative pressure (LBNP) were significantly different from the start (0 mmHg LBNP) between normothermic (92% CRM) and hyperthermic (43% CRM) conditions. Hyperthermic subjects exhausted their total reserve to compensate earlier (−60 mmHg) than normothermic subjects (−100 mmHg). These results indicate CRM has the ability to sense relative hypovolemia resulting from hyperthermia

  • We demonstrate here the utility of a wearable technology, CRM, developed for PFC in the military setting that can be translated to space exploration

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Summary

INTRODUCTION

THE COMPENSATORY RESERVE From laboratory experiments using LBNP, we have defined the “compensatory reserve” as an individual’s capacity to compensate for reductions in central hypovolemia.[10,11,12,26,45] A machineshunting blood to the heart and brain and subsequently learning (ML) based algorithm has been developed that progresses to cardiovascular collapse (shock) This response is provides a CRM, with real-time assessment of an individual’s highly individualized, so identifying those individuals with lower current physiological status. The CRM algorithm was human space exploration contexts, highlight the need for the developed using a large reference database of arterial wavedevelopment of advanced monitoring technologies to provide forms from each individual’s PPG signals, generated from our npj Microgravity (2019) 29

Reserve to Compensate
Physical exertion
DESIGN OF WEARABLE TECHNOLOGY FOR MEDICAL MONITORING
TRANSLATION TO SPACEFLIGHT MISSIONS
FUTURE RESEARCH FOR THE COMPENSATORY RESERVE
Tension Pneumothorax
CONCLUSION
AUTHOR CONTRIBUTIONS
Findings
ADDITIONAL INFORMATION
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