Abstract
karel hendrik wesseling ([Fig. 1][1]), emeritus professor of biomedical instrumentation, was born in The Hague, The Netherlands, on April 23, 1935. He studied electrical engineering, in his words, from 1950 on, and since 1953 at the Delft University of Technology (DUT) from which he graduated with
Highlights
KAREL HENDRIK WESSELING (Fig. 1), emeritus professor of biomedical instrumentation, was born in The Hague, The Netherlands, on April 23, 1935
A few researchers who knew him well briefly review some of the important contributions that Karel made to their field and how it helped in advancing science. (B.E.W.)
Karel’s motto in his professional life was “helping clinicians in their care for patients by providing them innovative, noninvasive concepts, methods and tools.”. Engineer, and innovator, he realized that to achieve a situation where tools would be widely available to clinicians, major investments in research and development (R&D) and product
Summary
Karel’s motto in his professional life was “helping clinicians in their care for patients by providing them innovative, noninvasive concepts, methods and tools.” As physicist, engineer, and innovator, he realized that to achieve a situation where tools would be widely available to clinicians, major investments in research and development (R&D) and product. In the 1970s, the development of his extensive model of the human circulation among other things led to the first method and algorithm for the beat-to-beat computation of cardiac output from the pressure waveform, the so-called Wesseling cZ method [39], which was patented, commercially licensed, and implemented in a patient monitor. H154 principle, finger cuff, method of calibration, proportional pneumatic control valve, and electronic light-emitting diode driver This unique set of intellectual property and patents again led to a commercial license and development of the Finapres 2300 patient monitor. Further R&D in this period led to a new concept of modeling the real-time flow waveform from pressure, resulting in the second generation method and algorithm for the beat-to-beat computation of cardiac output from the pressure waveform, the so-called Modelflow method [36], which was patented, commercially licensed and implemented in several patient monitors. When we continue the R&D and product development in this field, we stand on the shoulders of a giant. (J.J.S.)
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