Abstract
Chemical investigation of the EtOAc-soluble fraction from the MeOH/DCM extract of a cultured octocoral Briareum violaceum afforded two new briarane diterpenoids, briaviolides O (1) and P (2). The structures of briaranes 1 and 2 were elucidated on the basis of spectroscopic analysis, and 1 was shown to inhibit the accumulation of pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophage cells.
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