Abstract
Six new briarane-type diterpenoids, briarenolides E-J (1-6), were isolated from an octocoral Briareum sp. The structures of briaranes 1-6 were established by spectroscopic methods and by comparison the spectral data with those of known briarane analogues. It is worth noting that briarenolide E (1) is the first 2-ketobriarane, briarenolide F (2) is the first 6-hydroperoxybriarane, and briarenolide I (5) is the first 6-oxymethylbriarane analogues. Briarenolide E (1) displayed modestly inhibitory effects on the generation of superoxide anion and the release of elastase and briarenolide F (2) displayed a significant inhibitory effect on the generation of superoxide anion by human neutrophils.
Published Version
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