Abstract
In the current study, we investigated the breed difference of Sirt1 gene expression in liver and pancreas between Jinhua pigs (a local fatty breed of China) and Landrace (a leaner breed). In addition, the gene expression of lipid metabolism enzymes adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) has also been examined. Results showed that the serum triglyceride (TG), and total cholesterol (TCHO) concentration of Jinhua pigs were greater than Landrace while the serum glycerol in Jinhua pigs was lower at the age of 180d. The serum leptin concentration was also greater in Jinhua pigs. Compared with Landrace, the mRNA level and protein abundance of Sirt1 were lower both in liver and pancreas in Jinhua pigs. Consistent with Sirt1 expression, in liver and pancreas, the mRNA expression of lipolitic enzymes ATGL and HSL was always lower in Jinhua pigs than Landrace respectively. Furthermore, similar results were found in 60d pigs. The mRNA levels of Sirt1, ATGL and HSL were decreased in 60d Jinhua pigs comparatively. These results indicated that porcine Sirt1, as well as ATGL and HSL gene expressions are different between fatty and leaner pigs. This will provide useful information for better known of Sirt1 function in fat deposition.
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