Breathing new life into the rational design of Alzheimer’s therapeutics

Abstract

γ-secretase is a promising therapeutic target for Alzheimer's disease, but all inhibitors and modulators havefailed due to toxicity or low efficacy. In this issue of Cell, Yang etal. provide cryo-EM structures of γ-secretase bound to three inhibitors and a modulator, giving new promise to targeting γ-secretase therapeutically.