Abstract
With the use of new and improved analytical techniques, concentrations of acetaldehyde in antecubital venous blood and breath of human volunteers were measured after (a) pretreatment of subjects with ethanol and the aldehyde dehydrogenase inhibitor, calcium carbimide and (b) treatment with ethanol only. Breath acetaldehyde concentrations were converted to equivalent pulmonary blood concentrations using an experimentally determined blood: breath partition ratio for acetaldehyde of 190. Under all experimental conditions, blood acetaldehyde concentrations calculated from breath analysis were seen to closely reflect those measured by direct blood analysis. Treatment of subjects with calcium carbimide resulted in elevated blood and breath acetaldehyde concentrations which were rapidly lowered by the intravenous infusion of 4-methyl pyrazole. Peak blood acetaldehyde concentrations ranged from 25 to 188 μM after calcium carbimide and ethanol treatment, but were only 6–11 μM after ethanol treatment alone (1.2g/kg).
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