Abstract
Clinical manifestations commonly include abdominal and pelvic pain with bloating, distention, urinary urgency and frequency, and unintended weight loss in the presence of tenderness to palpation and an adnexal mass on bimanual examination. Risk factors for the development of ovarian cancer include early menarche, late menopause, nulliparity, and infertility. Additional risk factors include the BRCA1 and BRCA2 (breast cancer 1 and 2 gene) mutations, as well as Lynch syndrome.
Highlights
Ovarian cancer is the fifth most frequent diagnosis of female malignancy and the second most common female gynecologic malignancy after breast cancer [1,2]
The basis to the diagnosis of metastases of ovarian cancer to breast is that the papillary architecture consistent with serous papillary carcinoma is not a typical pattern of the majority of histological types of invasive breast carcinoma [6]
A study by Hadju and Urban involving 4,051 breast cancer patients found an overall incidence of primary gynecologic cancers metastatic to the breast of 0.17%, with only 0.07% of metastatic disease originating from a primary ovarian tumor [8]
Summary
Ovarian cancer is the fifth most frequent diagnosis of female malignancy and the second most common female gynecologic malignancy after breast cancer [1,2]. Metastasis to the breast from extramammary malignancies is rare; representing 0.2-1.3% of all malignant tumors diagnosed in the breast, [1] and arises most frequently from melanomas, sarcomas, lung cancer, ovarian tumors, and renal carcinomas [5]. A 45-year-old female came with complains of lump in lower abdomen since 3 months. It was insidious in onset and increased gradually over 3 months. It was not associated with any history of pain in abdomen or per vaginal discharge Her age at menarche was 14 years. Patient was investigated and found to have bilateral carcinoma ovary with pleural effusion on radiological examination. Biopsy of the lump revealed moderately differentiated adenocarcinoma with positivity for CA 125 and cytokeratin (Figure 1 and Figure 2)
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