Abstract
<h3>Introduction</h3> Breast implant-associated anaplastic large cell lymphoma is a histologically malignant neoplasm of CD30 positive T-cells that is classically ALK negative. It arises in association with the fibrous capsule or effusion around the implant. Case reports are increasing and knowledge of its behaviour, prognosis and significance is now becoming clearer. <h3>Case report</h3> A bilateral capsulectomy specimen was received from a 56-year-old woman. Notably, the inner surface of the left capsule showed a focal fibrinoid exudate on gross inspection. Histologically it consisted of a hyalinised collagenous substance lined by fibrinoid material containing loose aggregates of anaplastic large cells; some with immunoblastic morphology and others with reniform nuclei and basophilic cytoplasm. The abnormal cells expressed CD4, CD43, CD30, EMA and showed a Ki-67 proliferative index of >60%. They were negative for CD3, CD20, S100 and AE1/AE3. The overall features were diagnostic of implant-associated anaplastic large cell lymphoma. <h3>Conclusion</h3> This rare case is presented with a review of what has been elucidated so far in order to raise awareness among working pathologists of its existence, histological features, prognostic factors and recommendations of what to look for and report if it is ever encountered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
