Abstract
Background: Metastatic tumors are among the most common lesions in the brain. The pituitary gland is an uncommon site of metastasis for malignancies. Breast cancer is the most common primary neoplasm metastasizing to pituitary in women. It may cause hormonal problems in different patterns due to mass effect and invasion to the pituitary gland. Case Report: We report here a 47-year-old woman with estrogen receptor-positive, progesterone receptor-negative, of human epidermal growth factor-2-positive metastatic breast cancer being treated with palliative radiotherapy, immunotherapy, and antihormonal therapy. Conclusion: Pituitary metastasis is a rare event in cancer progression. Diabetes insipidus is the most important criterion for differentiation of pituitary metastasis from adenomas. Metastases to the pituitary gland from breast and lung primaries may indicate more advanced disease; however, despite this, localized radiotherapy nearly always needs to be considered to provide improvement in symptoms.
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