Abstract
Backgrоund. Breast cancer molecular subtypes serve as a basis for combined treatment of the disease. Some of them (e. g. triple negative subtype) are prognostically unfavorable. Recently, we’ve demonstrated role of bone marrow B-cells in breast cancer prognosis. Correlation between these parameters (molecular subtypes and bone marrow lymphocyte subpopulations) have not yet studied.Aim. To investigate prognostic role of breast cancer molecular subtypes and to see the relationships between these subtypes and subpopulational composition of bone marrow lymphocytes.Materials and methods. Detailed study of bone marrow has been performed in all 107 patients treated in breast cancer department of N.N. Blokhin National Medical Research Center of Oncology in 2013–2016 years. Distribution of patients according to molecular subtypes were as follows: Luminal A – 36 (33.6 %) pts, Luminal B HER2-negative – 38 (35.5 %), Luminal B HER2-positive – 15 (14 %), subtype with Erb-B2 hyper-expression – 5 (4.4 %), triple negative – 13 (12.1 %). Comparison of molecular subtypes with immunological parameters was done for the following bone marrow B-lymphocyte subpopulations: CD19+, CD19+CD10+, CD19+CD38+, CD19+CD5+. The following survival data were analyzed: overall survival, relapse-free survival, progression-free survival, metastasis-free survival.Results. Breast cancer molecular subtypes were not related to overall survival of patients but influenced relapse-free survival, progression-free survival and metastasis-free survival. There were no correlation between molecular subtypes and bone marrow B-lymphocyte subpopulations CD19, CD19+CD10+, CD19+CD38+. B1-lymphocytes were related to molecular subtypes, the levels of B1 cells were significantly higher in Erb-B2 subtype compared to triple-negative subtype (p = 0.039).Conclusion. Breast cancer molecular subtypes are different in prognosis – relapse-free survival, progression-free survival and metastasis-free survival. The most prognostically unfavorable is triple-negative subtype. There are some relationships of bone marrow subpopulations and molecular subtypes of breast cancer: levels of B1-cells are much higher in Erb-B2 subtype compared to triple negative subtype (p = 0.039).
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