Abstract
Breast cancers metastasizing to thyroid gland are relatively uncommon in clinical practice. Retrospective analysis of data from breast cancer patients with thyroid metastasis (TM). The US suspected, fine-needle aspiration cytology (FNAC) confirmed TM in breast cancer patients, treated between 2005 and 2015 at our hospital, was retrospectively analyzed. The data were re-evaluated by the pathologist and radiologist who were blinded to the patients' data. FNAC and immunohistochemistry confirmed the ultrasonography (US) suspected TM in eight breast cancer patients. Clinically both unilateral and bilateral TM was seen, which were symptomless and metachronously (6-121 months) metastasized. Six of eight cases exhibited recurrence/distant metastasis and were treated with chemotherapy/thyroidectomy of which two cases passed away. The remaining two patients had no recurrences/distant metastases and were treated with partial/total thyroidectomy. Post-chemotherapy US showed more homogenous thyroid parenchyma with gathering of calcification that reduced in size, revealing the sensitiveness of TM to chemotherapy. US was useful in screening TM in breast cancer patients. Both partial and total thyroidectomy was effective in disease free survival of isolated TM cases, with controlled primary condition. TM responded well to chemotherapy in most of the recurrent breast cancer cases with or without distant metastasis.
Highlights
Breast cancer is the leading cause of cancer related death in women
Clinical findings The study comprised of 8 female patients who were diagnosed with thyroid metastasis (TM) from breast cancer between 2005 and 2015
The details of recurrence/distant metastasis associated with TM, the timeline at which they were diagnosed in respect to TM and their treatment regimen are detailed in table 2
Summary
Breast cancer is the leading cause of cancer related death in women. In spite of its relatively early detection and treatment, distant metastasis to various tissues, including thyroid gland, still remains a challenge. @ 2017 Zhou et al; licensee African Health Sciences. Objective: Retrospective analysis of data from breast cancer patients with thyroid metastasis (TM). Methods: The US suspected, fine-needle aspiration cytology (FNAC) confirmed TM in breast cancer patients, treated between 2005 and 2015 at our hospital, was retrospectively analyzed. Results: FNAC and immunohistochemistry confirmed the ultrasonography (US) suspected TM in eight breast cancer patients. Both unilateral and bilateral TM was seen, which were symptomless and metachronously (6-121 months) metastasized. The remaining two patients had no recurrences/distant metastases and were treated with partial/total thyroidectomy. Conclusion: US was useful in screening TM in breast cancer patients Both partial and total thyroidectomy was effective in disease free survival of isolated TM cases, with controlled primary condition.
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