Breast cancer gene expression profile in young women who are noncarriers of BRCA1/2 mutations with and without familial history.

Abstract

1538 Background: Breast cancer (BC) in young women is associated with worse prognosis and positive family history of breast and/or ovarian cancer with risk gene mutations, particularly BRCA gene germline mutations. However mutations in the BRCA1/2 genes explain only 10% of BC cases diagnosed before 40 years. Little is known about the genetic basis of early-onset non carriers of BRCA1/2 familial or non-familial cases but aggressive tumor characteristics may be derived from specific oncogenic pathways. Based on these facts, our assumption was that in young (≤ 35 years) patients (pt), with or without familial history, molecular random events may modulate pathways involved in carcinogenesis. Methods: We evaluated gene expression profile in Brazilian young women with and without BC familial history, excluding those with BRCA 1/2 mutations. Thirty one pt with maximum 35 years were included, 50% with ER(-) tumors, 11 and 20 pt reported positive FH(+) and negative FH(-) familial history (NCCN criteria) for BC can...