Abstract
Werner's syndrome is an autosomal recessive disease with premature senility, scleroderma-like changes, characteristic habitus & stature, and often complicated with a malignant tumor. This paper reports on a very rare case of breast cancer as a complication in Werner's syndrome. A 48-year-old female was seen at our department because of 1cm tumor in A region of her left breast. The tumor was diagnosed as left breast cancer (T2a, No, Mo, stage II). Modified radical mastectomy was performed. Pathological diagnosis was solid-tubular carcinoma, f, s, no. DNA ploidy pattern was aneuploidy. Amplification of c-erbB-2 gene was not found. Postoperative course was uneventrul. We should entertain a possible association of breast cancer in the treatment of Werner's syndrome, though it occurs in a low frequency.
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