Abstract
Clinical Problem Ms P, a 38-year-old woman, is receiving tamoxifen for breast cancer. She has clinically significant anxiety and depression. She also suffers from tamoxifenrelated hot flashes. Paroxetine is an effective treatment for anxiety,1 depression,2 and menopausal hot flashes,3 including those related to tamoxifen.4 What are the concerns regarding the use of paroxetine (or other antidepressants) in patients receiving tamoxifen?
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