Abstract
Adenomyoepithelioma is a rare, benign proliferative tumour that can involve the breast. It is usually present as a solitary, unilateral, painless mass at the periphery of the breast in women range in age from 26 to 82 years (average 63 years). Tumour sizes range from 0.5 to 8 cm. (average size 2.5 cm).We report a case of adenomyoepithelioma of right breast in a 58 years old female since two months with diagnostic difficulty on cytology, especially with morules predominance that merits documentation due to its rarity. On physical examination, it was a single well defined, lobulated, non mobile, firm mass of 10 x 8 x 5 cm in upper outer quadrant of right breast without associated axillary lymphadenopathy. Sonomammography showed well defined lobulated right breast mass with macrolobulations and cystic changes suggestive of phyllodes tumour. Wide local excision was performed and histopathological study revealed adenomyoepithelioma which is confirmed by P63 immunostain. DOI: 10.21276/APALM.1311
Highlights
We are presenting a case of adenomyoepithelioma breast with diagnostic difficulty on cytology, especially with morules predominance
Adenomyoepithelioma of breast was first reported by Hamprel in 1970,more than 60 cases had been reported since [1].It is a rare tumour characterized by biphasic proliferation of an inner layer of epithelial cells and a prominent peripheral layer of myoepithelial cells
Adenomyoepithelioma may be detected by sonomammography but it is in apparent on mammography
Summary
We are presenting a case of adenomyoepithelioma breast with diagnostic difficulty on cytology, especially with morules predominance. Adenomyoepithelioma of breast was first reported by Hamprel in 1970,more than 60 cases had been reported since [1].It is a rare tumour characterized by biphasic proliferation of an inner layer of epithelial cells and a prominent peripheral layer of myoepithelial cells. It is benign but occasionally may have malignant potential. Immunostain for P63 showed strongly positive nuclear reactivity in the proliferating myoepithelial cells, while the epithelial cells fail to react confirming a diagnosis of adenomyoepithelioma(Figure 4). Annals of Pathology and Laboratory Medicine, Vol 4, Issue 6, November-December, 2017
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