Abstract
On January 28 in Nature online, Zheng et al. (Nature, 2021 (Online ahead of print)) reported that they developed an ingenious method of interspecies PSC co-culture system in vitro which unfolded interspecific cell competition. This study paves the way for discovering the mechanism of interspecific chimera and for further interspecific organogenesis between evolutionarily distant species.
Highlights
Pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs), induced pluripotent stem cells, and epiblast stem cells (EpiSCs), are very promising resources for study of mammalian embryonic development and regenerative medicine
Wang et al attested that overexpression of BCL2L1 and BCL-2 in human PSCs (hPSCs) could efficiently construct human-mouse chimeras (Wang et al 2018). Wu and his colleagues demonstrated that, unlike naïve hPSCs, the intermediate hPSCs could contribute to chimeras and produce differentiated descendants in post-implantation pig embryos (Wu et al 2017)
On the basis of this study, they recently established an ingenious method of interspecies PSC co-culture system to unfold interspecific cell competition (Zheng et al 2021 (Online ahead of print))
Summary
Pluripotent stem cells (PSCs), such as embryonic stem cells (ESCs), induced pluripotent stem cells, and epiblast stem cells (EpiSCs), are very promising resources for study of mammalian embryonic development and regenerative medicine. During interspecific chimera formation, cell competition between xenogenic donor cells and host cells plays a critical role. They speculated that hPSCs might have undergone apoptosis in xenogeneic embryos.
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