Breakthrough evidence based on the dual allergen exposure hypothesis-both skin intervention and oral intervention.

Abstract

Early-onset atopic dermatitis increases the risk of food allergies, suggesting that transcutaneous sensitization may occur through inflamed skin. Regarding food allergy causation, the dual allergen exposure hypothesis proposes that oral-route allergen exposure leads to immune tolerance, whereas allergen exposure via the inflamed skin causes food allergy. This hypothesis implies that it is important to induce oral immune tolerance and prevent allergic food sensitization through the skin. In this review, we focus on the breakthrough evidence based on the dual allergen exposure hypothesis-both skin intervention and oral intervention for food allergy prevention.