Abstract

Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. Here we attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains—the world’s most abundant food source—can affect human behavior and mental health. We present the implications for the psychological sciences of the findings that, in all of us, bread (1) makes the gut more permeable and can thus encourage the migration of food particles to sites where they are not expected, prompting the immune system to attack both these particles and brain-relevant substances that resemble them, and (2) releases opioid-like compounds, capable of causing mental derangement if they make it to the brain. A grain-free diet, although difficult to maintain (especially for those that need it the most), could improve the mental health of many and be a complete cure for others.

Highlights

  • Perhaps because gastroenterology, immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition

  • Abnormally high levels of milk and/or wheat exorphins have been found in the urine (Hole et al, 1979) and blood (Drysdale et al, 1982) of schizophrenia patients and in the urine (e.g., Sokolov et al, 2014; but see Cass et al, 2008) of autistic children

  • Besides producing behavioral disorders similar to those seen in schizophrenia and autism, exorphins activate in rats the same brain regions that are affected in schizophrenia and autism

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Summary

Bread and Other Edible Agents of Mental Disease

Immunology, toxicology, and the nutrition and agricultural sciences are outside of their competence and responsibility, psychologists and psychiatrists typically fail to appreciate the impact that food can have on their patients’ condition. We attempt to help correct this situation by reviewing, in non-technical, plain English, how cereal grains—the world’s most abundant food source—can affect human behavior and mental health. We present the implications for the psychological sciences of the findings that, in all of us, bread (1) makes the gut more permeable and can encourage the migration of food particles to sites where they are not expected, prompting the immune system to attack both these particles and brain-relevant substances that resemble them, and (2) releases opioid-like compounds, capable of causing mental derangement if they make it to the brain.

INTRODUCTION
HOLES IN OUR GUT
IMMUNE SYSTEM MISTAKES
The Many Forms of Wheat Sensitivity
Wheat and the Mind
Microbial Accomplices
BREAD AND OTHER DRUGS
Exorphins Posing as Endorphins
Too Much Exorphin in the Wrong Place
DIET AS A CURE
Findings
CONCLUSION
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