Abstract
The review summarizes information about the effects of ligand-receptor interaction in the normal state, during maladaptation and pathology. The mechanisms of changes in the functions of the receptors of the immune system that recognize pathogen patches, interact with immunoglobulins and participate in the immune response are shown. Data on interactions within the neurotransmitter systems of the brain are presented. The properties of lectins, follicle-stimulating hormone, progesterone derivatives and calcitonin are considered. The review also summarizes information on such cellular processes as cell growth, bone regeneration and remodeling, apoptosis. The role of thiazole retinoids in the regulation of cell differentiation and signaling pathways has been shown. Particular attention is paid to angiogenesis and vascular endothelial growth factor, receptors and ligands to fibroblast growth factor, galactins involved in oncotransformation processes. It was established that phosphatase with the Src2 homology domain (SHP2) is an important component of oncogenic signaling pathways. The mechanism of multivalent interaction of bacteria and viruses with the cells of the body is discussed. The interaction of nanoparticles (graphene, fullerenes) with biological objects is considered in sufficient detail. The article discusses the problem of receptor saturation and the activity of ex-orphan receptors that can act as targets for potential drugs. The prospects of creating new drugs based on π-cation interactions are shown. It was concluded that the study of the interaction of the substance and the receptor will allow to reveal the true mechanisms of dysregulatory pathology.
Highlights
В обзоре обобщены сведения об эффектах лиганд-рецепторного взаимодействия в состоянии нормы, при дезадаптации и патологии
Particular attention is paid to angiogenesis and vascular endothelial growth factor, receptors and ligands to fibroblast growth factor, galactins involved in oncotransformation processes
It was established that phosphatase with the Src2 homology domain (SHP2) is an important component of oncogenic signaling pathways
Summary
Нарушение лиганд-рецепторного взаимодействия в патогенезе дезадаптивных расстройств и при патологии. В обзоре обобщены сведения об эффектах лиганд-рецепторного взаимодействия в состоянии нормы, при дезадаптации и патологии. Достаточно подробно рассмотрено взаимодействие наночастиц (графена, фуллеренов) с биологическими объектами, а также проблема насыщения рецепторов и деятельности экс-орфанных рецепторов, которые могут выступать мишенями для потенциальных лекарственных средств. Что изучение взаимодействия вещества и рецептора позволит раскрыть истинные механизмы дисрегуляторной патологии. Breach of ligand-receptor interaction in pathogenesis of disadaptive disorders and in pathology. The review summarizes information about the effects of ligand-receptor interaction in the normal state, during maladaptation and pathology. It was concluded that the study of the interaction of the substance and the receptor will allow to reveal the true mechanisms of dysregulatory pathology. Keywords: disadaptation; chemical bond; receptors; ligands; interaction; molecular effects
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