Abstract
Objective: A subset of sporadic ovarian carcinoma (OC) may harbor anomalies of the homologous recombination (HR) pathway that could be associated with improved response rate and survival after treatment with platinum drugs. The proteins defining this BRCAness profile of sporadic OC have not been clearly defined, nor has the mechanism by which OC develops defective HR been elucidated. The objective of the study was to determine whether expression of PARP, FANCD2, PTEN, H2AX, ATM and P53 proteins in ovarian cancer correlates with response to treatment, recurrence rate, and survival.
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