Abstract
Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs). Recent evidence suggests that association with unique meiosis-specific cofactors allows BRCA2 to facilitate homologous recombination in germ cells.
Highlights
Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs)
A central regulator of homologous recombination (HR) is the cancer suppressor BRCA2, which promotes the homologydirected repair of DSBs by loading RAD51 recombinase onto the single-strand DNA (Figure 1A) [2]
The expression of truncated forms of BRCA2 containing the MEILB2-binding domain (MBD) showed that BRCA2 localizes to meiotic HR sites in spermatocytes in an MEILB2-dependent manner [4]
Summary
Breast cancer type 2 susceptibility protein (BRCA2) is a central regulator of homologous recombination in somatic cells and safeguards genomic integrity against DNA double-strand breaks (DSBs). Recent evidence suggests that association with unique meiosis-specific cofactors allows BRCA2 to facilitate homologous recombination in germ cells
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