BRCA1-BRCA2 mutation analysis results in 910 individuals: Mutation distribution and 8 novel mutations

Abstract

•BRCA1/2 mutations detected nearly 10 percent of the patients who underwent testing. •Family history and age of diagnosis are the most important risk factors for BRCA1/2 mutation. •Sequencing analysis of large exons (BRCA1-exon 10, BRCA2-exon 11) could detect more than half of mutations.