Abstract
ObjectiveIn this study, we aimed to investigate the predictive effect of BRCA1, STMN1, MAPT and TUBB3 on the prognosis of patients with non-small cell lung cancer (NSCLC).MethodsSeventy NSCLC patients who received platinum-based chemotherapy from June 2009 to July 2011 were enrolled. The protein and mRNA levels of BRCA1, STMN1, MAPT and TUBB3 were determined. Survival time of the patients with NSCLC was also calculated.ResultsHigh expression of BRCA1 or low expression of STMN1 was associated with a better prognosis in NSCLC patients (p<0.01). In contrast, the expression of MAPT and TUBB3 were not closely related with the prognosis of NSCLC patients(p>0.05). Furthermore, patients with high expression of BRCA1 and low expression of STMN1 have lived longer (p<0.01).ConclusionBRCA1 and STMN1 were independently predictors for prognosis of NSCLCs which received cisplatin-based adjuvant chemotherapy.
Highlights
Lung cancer is one of the most frequent malignant neoplasm and it was the main cause of cancer-related death all over the world [1]
High expression of breast cancer 1 (BRCA1) or low expression of STMN1 was associated with a better prognosis in non-small cell lung cancer (NSCLC) patients (p
Tissue microarray statistical results showed that the expressions of BRCA1 and MAPTin cancer tissues were significantly lower (p
Summary
Lung cancer is one of the most frequent malignant neoplasm and it was the main cause of cancer-related death all over the world [1]. NSCLC accounts for approximately 85% of all lung cancer. Most of the patients diagnosed with NSCLC have advanced local invasion and/or distant metastases at the time of diagnosis. Despite of recent improvement in surgery, chemotherapy, radiotherapy techniques, the long-term time of NSCLCs is still not satisfied. The 5-year survival rate of NSCLCs stayed at approximately 16% and was accompanied by high recurrence rate, it has no significant improvement during the last two decades [2,3,4]. The high morbidity and mortality of NSCLCs made a great threat to the health and life of populations
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