Abstract
<p indent="0mm">DNA damage response contributes to the maintenance of genomic stability in individuals. As an important tumor suppressor gene, <italic>BRCA1</italic> plays a crucial role in DNA damage response. BRCA1 upon binding to BARD1 forms a stable heterodimer which is the core component of BRCA1 functional complex. BRCA1 takes part in the regulation of DNA damage signaling transduction, homologous recombination, DNA replication, and cell cycle. In this review, we have described BRCA1’s function and its involvement in the regulation of DNA damage response network. Furthermore, we have summarized the various mechanisms of PARP inhibitors’ resistance in tumors with BRCA1 mutated.
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