Abstract
Fogo Selvagem (Wildfire) is a cutaneous disease characterized by a specific epidemiology, generalized distribution of bullae followed by an exfoliative erythroderma, and frequently, a grave prognosis, if untreated. Its etiology is unknown and the pathogenesis only partly understood. The histopathologic hallmark is the presence of acantholysis in the superficial layers of the epidermis. The acantholysis is due to the binding of immunoglobulin to the intercellular cement substance of the epidermis.
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