Abstract
The term "schizophrenia" should be used to refer to a group of neurodevelopmentally mediated cognitive disorders. Although these disorders may have different etiologies, the final causal pathway is characterized by a cognitive triad of (working memory, corollary discharge, and inhibition) deficits. Biomarkers can be used to lend insights regarding underlying pathophysiology, and lead to more precise definitions of schizophrenia subtypes. Use of endophenotypes (i.e., traitlike heritable markers of liability) that are specific to schizophrenia would aid us in our search for these biomarkers by providing a means to classify more homogeneous groups of schizophrenia patients.
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