Brassiodol: A new iodised oil for eradicating endemic goiter

Abstract

A new iodised oil called Brassiodol is proposed to prevent or eradicate 127I-deficiency disorders. Its original synthesis utilises rapeseed oil as a vehicle of iodination, allowing the covalent binding of 127I atoms to all olefin groups of fatty acids (FAs). The final product contains 376 mg 127I/mL, manifests high refractoriness to degradative processes, and is well tolerated by goitrous patients. The proposed dosage is 1 mL/year in adults owing to the rapid deiodination and massive 127I leakage of larger amounts in the urinary output. About 300–350 mg 127I may undergo tissue sequestration, insuring appropriate iodine coverage during 9–12 months. Clinical follow-up, hormonal data, and 127I excretory kinetics point to the normalisation of thyroid function within 3 months in stages I and II of the goitrous disease. This iodised oil, characterised by low cost, easy handling, and high nutritional efficiency, seems ideally suited to meet public health and economical problems in those countries with severe goitrous areas. J. Trace Elem. Exp. Med. 13:85–96, 2000. © 2000 Wiley-Liss, Inc.