Brassica oleracea var.acephala of kashmir as a promising candidate for improvement of lipid profile associated with hyperglycemia through in vivo study in male albino rats

Abstract

Diabetes mellitus commonly considered as clandestine killer is a metabolic disorder that affects people all over the world and is a silent killer. A variety of treatments are available, including insulin and oral anti-diabetic medications for regulating blood sugar levels in the body but every treatment option has certain unfavorable side effects that might cause abnormalities with the macro and microvascular systems in the human body. Kale (Brassica oleracea var. acephala) from the brassica family is gaining popularity due to its phytochemical content and ability to prevent many ailments, notably those brought on by oxidative stress. The current study assessed Brassica oleracea var acephala of the UT of Kashmir locally known as khanyari as it is loaded with various bioactive substances including total phenols, flavonoids, and glucosinolates that impart antioxidant and antidiabetic properties. Kale(K-29) showed impressive results in normalizing the blood glucose levels(102.30mg/dl) as well as improving the lipid profile such as cholesterol(76.22mg/dl), HDL(36.4mg/dl), LDL(36.1mg/dl), VLDL(21.2mg/dl) and triglycerides(85.40mg/dl) that is usually accompanied with hyperglycemia. The treatment of K-29 also showed improvisation in the various hepatic parameters such as S.G.P.T(91.14), S.G.O.T (41.18), Alkaline phosphatase (102.32U/L), Albumin (6.12g/dl), S. bilirubin direct(0.6mg/dl), S. bilirubin indirect(0.43mg/dl).