Abstract
SAVORY in 1856 published a paper dealing with 'a young woman in whom the main arteries of both upper extremities and of the left side of the neck were throughout completely obliterated'. This was apparently the first report of a disease which later by TAKAYASHU (1908) was suggested as being a pathologic and clinical entity. Comprehensive studies on the subject, including reviews of the literature, have been published among others by ASK-UPMARK (1954), ASKUPMARK & FAJERS (1956) and KOSZEWSKI (1958). The number of cases which, rightly or wrongly, are reported as examples of the disorder is about 150 ; about ten of them were confirmed by postmortem examination. The disease is characterized by a chronic, progressive inflammatory process in the aortic arch as well as in the carotid, subclavian and axillary arteries. The etiology of the disease is unknown. There is panarteritis with round cell infiltration in the periarterial tissues and all layers of the vessel wall. Subsequent thrombosis frequently develops. With few exceptions the condition is reported in young or middle-aged females. The symptoms and signs are both general and local, the former including a high erythrocyte sedimentation rate (ESR)
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