Abstract
The metabolism of l-leucine in pancreatic islets is reviewed. Regulatory sites may involve (i) the transport and intracellular distribution of l-leucine, (ii) its transamination as modulated by the availability of 2-keto acids, (iii) the activity of branched-chain 2 keto acid dehydrogenase and (iv) the further catabolism of isovaleryl coenzyme A. Emphasis is also placed on the activation of glutamate dehydrogenase by l-leucine, its interference with the utilization of endogenous nutrients and the reciprocal effects of l-leucine and either l-glutamine or l-asparagine upon their respective metabolism. The relevance of l-leucine metabolism to its insulinotropic action is underlined.
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