Branched Chain Amino Acids in Clinical Nutrition

Abstract

Part I. Basic Processes at the Cellular Level.- 1. Impact of dietary essential amino acids in man.- 2. Metabolism of BCAAs.- 3. The cytosolic and mitochondrial branched chain aminotransferase.- 4. Isoleucine, PPAR and uncoupling proteins.- 5. Leucine as a stimulant of insulin.- 6. Effects of leucine and isoleucine on glucose metabolism.- 7. Hypothalamic leucine metabolism in the regulation of liver glucose metabolism.- 8. Leucine and resveratrol: experimental model of sirtuin pathway activation.- 9. Branched chain amino acids and blood ammonia.- 10. Use of 2H3-leucine to monitor apoproteins.- Part II. Inherited Defects in Branched Chain Amino Acid Metabolism.- 11. Branched chain amino acid oxidation disorders.- 12. Branched chain amino acids and maple syrup urine disease.- 13. Mental retardation and isoleucine metabolism.- 14. Anorexia and valine-deficient diets.- Part III. Experimental models of growth and disease states: Role of Branched Chain Amino Acids.- 15. Leucine and fetal growth.- 16. Enteral leucine and protein synthesis in skeletal and cardiac muscles.- 17. Use of branched chain amino acids granules in experimental models of diet-induced obesity.- 18. Experimental models of high fat obesity and leucine supplementation.- 19. Branched chain amino acids in experimental models of amyotrophic lateral sclerosis.- 20. Leucine and ethanol oxidation.- 21. Isoleucine, leucine and their role in experimental models of bladder carcinogenesis.