Abstract
The present study summarizes the formation and characterization of multilayers of polyacrylonitrile (PAN) membranes with β-cyclodextrin derivatives in order to be potentially interesting for triclosan (TR) controlled delivery with antibacterial purposes, as well as, for the removal of TR from wastewater. With this object, cationic and anionic branched β-cyclodextrins (bβCDs) were incorporated by layer-by-layer (LbL) process onto previously synthesized and hydrolyzed PAN membranes. FTIR, XPS and labelling with fluoresceinamine (FA) let to study the formation and stability of the prepared multilayered systems. TR is a widely used antibacterial and antifungal agent with proven ability to inhibit bacterial growth that, however, recently has shown a potential toxicity. The ability of obtained bβCDs/PAN multilayered membranes to retain TR in water was evaluated by two different loading procedures. The delivery kinetic profile of TR from loaded membranes was also analyzed showing the maximum release in the first 24h.
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