Abstract
Background/aim The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects.Materials and methods This prospective study included 43 patients with BRVO (Group 1) and 40 control subjects (Group 2). The levels of MPV, PDW, and PCT were measured in both of the studied groups.Results The mean serum level of MPV value was 7.64 ± 0.64 in Group 1 and 7.39 ± 0.42 in Group 2. Mean serum level of PDW was 15.01 ± 1.56 in Group 1 and 14.43 ± 1.03 in Group 2. Mean serum PCT value was 0.19 ± 0.05 in Group 1 and 0.16 ± 0.04 in Group 2. MPV, PDW, and PCT levels were significantly increased in BRVO patients (P < 0.05).Conclusion Subclinical platelet activation reflected by MPV, PDW, and PCT may have an impact on the genesis of vessel occlusion in BRVO. The results may be important for the clinical management of patients with BRVO.
Highlights
Retinal venous occlusion is the second most common retinal vascular disorder after diabetic retinopathy causing visual loss [1]
Background/aim: The aim of this study is to study subclinical platelet activation by detecting three important platelet activation parameters of mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with branch retinal vein occlusion (BRVO) in comparison to those in healthy control subjects
MPV, PDW, and PCT levels were significantly increased in Branch retinal vein occlusion (BRVO) patients (P < 0.05)
Summary
Retinal venous occlusion is the second most common retinal vascular disorder after diabetic retinopathy causing visual loss [1]. Branch retinal vein occlusion (BRVO) is a frequent retinal vascular disease with a yearly incidence of 2.14/1000 in the population over 40 years of age [2]. Hypertension and end-organ damage caused by diabetes mellitus contribute to arteriosclerosis, atherosclerosis, and endothelial dysfunction, which seem to be major risk factors for BRVO [3]. Ophthalmic risk factors are ocular hypertension, glaucoma, higher ocular perfusion pressure, and changes in the retinal arteries [4]. Endothelial dysfunction and platelet activation lead to occlusion of branch retinal veins [6,7]
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