Brain-Wide Diffuse Optical Tomography Based on Cap-Based, Whole-Head fNIRS Recording.

Abstract

Diffuse optical tomography (DOT), based on functional near-infrared spectroscopy, is a portable, low-cost, noninvasive functional neuroimaging technology for studying the human brain in normal and diseased conditions. The goal of the present study was to evaluate the performance of a cap-based brain-wide DOT (BW-DOT) framework in mapping brain-wide networked activities. We first analyzed point-spread-function (PSF)-based metrics on a realistic head geometry. Our simulation results indicated that these metrics of the optode cap varied across the brain and were of lower quality in brain areas deep or away from the optodes. We further reconstructed brain-wide resting-state networks using experimental data from healthy participants, which resembled the template networks established in the fMRI literature. The preliminary results of the present study highlight the importance of evaluating PSF-based metrics on realistic head geometries for DOT and suggest that BW-DOT technology is a promising functional neuroimaging tool for studying brain-wide neural activities and large-scale neural networks, which was not available by patch-based DOT. A full-scope evaluation and validation in more realistic head models and more participants are needed in the future to establish the findings of the present study further.Clinical relevance- Via simulations and experimental evaluation, this work establishes a novel framework to image large-scale brain networks, which benefits the patient population, such as bedridden patients, infants, etc., who otherwise cannot undergo conventional brain monitoring modalities like fMRI and PET.