Abstract
Stroke is one of the most deliberating causes of mortality and disability worldwide. Studies have implicated Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene as a genetic factor influencing stroke recovery. Still, the role of BDNF polymorphism in poststroke aphasia is relatively unclear. This review assesses the recent evidence on the association between the BDNF polymorphism and aphasia recovery in poststroke patients. The article highlights BNDF polymorphism characteristics, speech and language interventions delivered, and the influence of BNDF polymorphism on poststroke aphasia recovery. We conducted a literature search through PubMed and Google Scholar with the following terms: “brain derived-neurotrophic factor” and “aphasia” for original articles from January 2000 until June 2020. Out of 69 search results, a detailed selection process produced a total of 3 articles that met the eligibility criteria. All three studies included Val66Met polymorphism as the studied human BDNF gene. One of the studies demonstrated insufficient evidence to conclude that BDNF polymorphism plays a role in poststroke aphasia recovery. The remaining two studies have shown that Met allele genotype (either single or double nucleotides) was associated with poor aphasia recovery, in either acute or chronic stroke. Carriers of the Val66Met polymorphism of BDNF gave a poorer response to aphasia intervention and presented with more severe aphasia.
Highlights
Stroke is one of the leading causes of death and acquired disability globally [1]
One genetic variation of interest is the Val66Met single-nucleotide polymorphism of the brain-derived neurotrophic factor (BDNF) gene in humans, a potential clinically significant genetic variation associated with stroke risk and prognosis [3]
The main impetus of the present review is to investigate whether BDNF Val66Met polymorphism is associated with language function in people with poststroke aphasia
Summary
Many demographic and clinical factors have influenced poststroke recovery, including age, stroke severity, presence of cognitive impairment, and neuropsychological deficits [2]. There is an emerging interest in studying genetic factors and variations that influence stroke susceptibility and recovery [3]. One genetic variation of interest is the Val66Met single-nucleotide polymorphism of the brain-derived neurotrophic factor (BDNF) gene in humans, a potential clinically significant genetic variation associated with stroke risk and prognosis [3]. BDNF, being part of the neurotrophin family of growth factors, is believed to influence a wide range of aspects of the nervous system, including but not limited to neuronal migration, dendritic growth, synapse maintenance, and long-term plasticity [5]. The number of clinical research studies of the role of BDNF polymorphisms in stroke is limited, and the exact influence of BDNF
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