Brain white matter and resting state eeg markers are abnormal in HIV subjects with relatively good cognitive status

Abstract

AbstractBackgroundThis retrospective and exploratory study tested the concept that at the group level, human immunodeficiency virus (HIV) can significantly affect brain structure and function before the manifestation of significant cognitive deficits.MethodFrom a multicenter database, we selected structural 3T magnetic resonance imaging (MRI) and resting state eyes‐closed electroencephalographic (rsEEG) datasets in 30 HIV‐positive (HIV) subjects with relatively good cognitive status and serological markers (i.e., HIV‐RNA copies and CD4 count). Control datasets of matched non‐infected subjects included rsEEG (N = 50) and MRI (N = 30) recordings. MRI markers of interest in HIV were derived from gray matter (GM) volume decrements and white matter (WM) lesion load, while rsEEG markers were cortical source current density estimated by LORETA freeware at relevant delta (< 4 Hz) and alpha (6‐12 Hz) individual frequency bands.ResultIn the HIV group, the subjects exhibited no abnormal score in neuropsychological tests. However, those subjects showed brain GM volume and WM abnormalities correlated with serum CD4 count (Figure 1). They also showed diffuse abnormalities in rsEEG alpha source activities.ConclusionAt the group level, HIV subjects with relatively good cognitive status can show abnormalities in both structural MRI and rsEEG markers. If cross‐validated in longitudinal studies, combined MRI and rsEEG markers may be a useful surrogate endpoint to test antiretroviral therapies with putative neuroprotective function.