Abstract
Cerebral, cerebellar, and hippocampal volumes were measured by quantitative magnetic resonance imaging on 112 children, ages 4-18 years, with epilepsy syndromes, determined by video-EEG telemetry, at Sydney Children’s Hospital, Randwick; St Vincent’s Hospital, Victoria; and New Children’s Hospital, Westmead, New South Wales, Australia.
Highlights
Cerebellar, and hippocampal volumes were measured by quantitative magnetic resonance imaging on 112 children, ages 4-18 years, with epilepsy syndromes, determined by video-EEG telemetry, at Sydney Children's Hospital, Randwick; St Vincent's Hospital, Victoria; and New Children's Hospital, Westmead, New South Wales, Australia
Hippocampal asymmetry was more sensitive than volume reduction as a marker for mesial temporal lobe epilepsy
Volume reduction was independent of age of onset and duration of epilepsy, suggesting that brain volume reduction is present at the onset of epilepsy and is not the result of intractable seizures
Summary
Cerebellar, and hippocampal volumes were measured by quantitative magnetic resonance imaging on 112 children, ages 4-18 years, with epilepsy syndromes, determined by video-EEG telemetry, at Sydney Children's Hospital, Randwick; St Vincent's Hospital, Victoria; and New Children's Hospital, Westmead, New South Wales, Australia. (Respond: Dr Finn Ebbesen, Department of Paediatrics, University Hospital of Aalborg, DK-9000 Aalborg, Denmark). A recent increase in the cases of kernicterus in term or nearterm infants in Denmark has raised concerns regarding the primary and secondary healthcare recognition and management of the problem.
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